Tottenham will kick off against Nottingham Forest on Friday, while Aston Villa travel to Brentford after impressive wins over Manchester City and Arsenal.
Here are three talking points ahead of the match.
Manchester United enter the lion’s den
Struggling Manchester United, who left Anfield with their tails tucked after a 7-0 rout last season, face a Liverpool team who are top of the Premier League and full of confidence.
Erik ten Hag’s team, who were dumped out of Europe by Bayern Munich this week, have lost 12 of their 24 matches in all competitions this season. 1472 six times behind fourth-placed Manchester City.
But they will travel to Anfield with trepidation. With the exception of a 2-1 win at Old Trafford last season, United’s recent results against Liverpool have been abysmal – they have lost four of the last five meetings while conceding 21 goals.
Liverpool are everything United are not: waspsture in front of goal, full of belief in themselves and with a never-die attitude that has helped them win 18 points from losing positions this season.
Ten Hag has ur After three defeats in their last four matches, the Blues, who host Sheffield United on Saturday, are 12th in the table, sitting much closer to the relegation zone than the top of the table in terms of points.
Pochettino, who is spending his first season at the club, believes Chelsea need to look again in the January transfer window, regardless of thevictories, but the Blades, led by the recently returned Chris Wilder, beat Brentford last week for only their second win of the season.
147 in just two of their eight Championship matches at Stamford Bridge.
Dyche proves to be the man for Everton crisis
Last month the Premier League dropped Everton 10 points for breaching financial rules, leaving them in 19th place in the table, level with Burnley, who were bottom at the time.
But three straight wins have lifted the Goodison Park club four points above the relegation zone and they are now looking up rather than down.
Everton have won nine of their last 13 matches in all competitions.1 Sunday: Arsenal v Brighton, Brentford v Aston Villa, West Ham v Wolves, Liverpool v Manchester United.
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