Their 4-1 victory over perennial leaders at the Etihad snatched control of the race out of Arsenal’s hands and put City in charge of their destiny.
But City boss Pep Guardiola takes too long to believe that a fifth league title in six seasons is a formality.
The reaction to City’s victory in the so-called decisive title match was clear. It was their seventh consecutive league win and they were two points behind Arsenal with two games to spare, when just recently they were eight behind.
A tireless City win over Fulham on Sunday would put them in the lead and if they achieve that, the title will indeed be lost, especially with home games against struggling West Ham United and Leeds United.
But Guardiola urges caution.
I have a feeling the next three games will determine a lot, he said. Fulham come from the Championship and have been just great this season. We play at home against Leeds and West Ham. We feel comfortable here because of the crowd.
After defeating City, Arsenal have the weekend to lick their wounds and regroup after their home match against Chelsea was postponed to Tuesday on the advice of the police.
But there is no respite for teams fighting at the other end of the table to avoid relegation.
Time seems to be running out for the Southampton club after Thursday’s defeat to Bournemouth left them six points from the safety zone for their five remaining games.
On Sunday, Southampton travels to third-place Newcastle United to face a team that has scored 10 goals in two games and appears to be on the verge of a return to the Champions League.
The two clubs directly above the Saints, Everton and Leicester City, meet Monday in a true six-goal match.
Nottingham Forest got out of the relegation zone thanks to a priceless win over Brighton & Hove Albion on Wednesday, and a win over Brentford on Saturday will put even more pressure on Everton and Leicester.
Leeds, who are ahead of Forest on goal difference, travel to almost safe Bournemouth on Sunday.
With Fulham comfortably in 10th place and Bournemouth and Forest on their way to survival, this could be only the fourth time in Premier League history that all three teams out of the championship have avoidedt departure in his first season.
Last time Fulham avoided relegation for the first time in Premier League history in its first season.In 2017-18, when Newcastle, Brighton and Huddersfield held on to the top, there was appendicitis.
Tottenham Hotspur’s chances of reaching the top four are all but lost, although they showed some fight, playing to a 2-2 draw with fourth-place Manchester United on Thursday in Ryan Mason’s first game as interim manager, four days after a 6-1 loss to Newcastle.
Fifth-place Spurs face seventh-place Liverpool on Sunday in a match that could largely decide which of these two clubs can save a place in Europa League qualification.
Tottenham has 54 points, the same number as sixth-place Aston Villa, while Liverpool has 53 points as it played one less game.
Liverpool are aiming for a fourth consecutive win and enter the Premier League as of late.
This season has taught us lessons I didn’t want to learn, but the most important lesson in soccer is to get three points at the weekend or midweek, manager Jurgen Klopp said.